Chemistry Organic Building Blocks Trifluoromethyls 2-(Trifluoromethoxy)Benzoic Acid

2-(Trifluoromethoxy)Benzoic Acid

These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —OCF3,—COOH).

Electrophilic Aromatic Substitution (EAS): Trifluoromethoxybenzene can undergo EAS reactions, where an electrophile replaces one of the hydrogen atoms on the benzene ring. This is a typical reaction for aromatic compounds, and the specific product will depend on the choice of the electrophile and reaction conditions.
Friedel-Crafts Acylation: Benzoic acid can undergo Friedel-Crafts acylation reactions with aromatic compounds in the presence of a Lewis acid catalyst such as aluminum chloride (AlCl3). This reaction results in the introduction of an acyl group (RCO-) onto the aromatic ring.

Further Reading:

Framework+−

(2,2,2-Trifluoroethoxy)Benzene (2-(Trifluoromethoxy)Phenyl)Boronic Acid (2-(Trifluoromethyl)Phenyl)Boronic Acid (2-(Trifluoromethyl)Phenyl)Methanol (2-Fluoro-3-(Trifluoromethyl)Phenyl)Boronic Acid (3-(Trifluoromethoxy)Phenyl)Boronic Acid (3-(Trifluoromethoxy)Phenyl)Methanol (3-(Trifluoromethyl)Phenyl)Boronic Acid (3-(Trifluoromethyl)Phenyl)Methanol (4-(Trifluoromethyl)Phenyl)Boronic Acid (Perfluoropropane-2,2-Diyl)Dibenzene (Trifluoromethyl)Benzene 1,3-Bis(Trifluoromethyl)Benzene 1-(2-(Trifluoromethyl)Phenyl)Ethan-1-One 1-(3-(Trifluoromethoxy)Phenyl)Ethan-1-Amine 1-(3-(Trifluoromethyl)Phenyl)Ethan-1-Amine 1-(4-(Trifluoromethoxy)Phenyl)Ethan-1-Amine 1-(Bromomethyl)-2-(Trifluoromethyl)Benzene 1-(Bromomethyl)-3-(Trifluoromethyl)Benzene 1-Bromo-2-(Trifluoromethoxy)Benzene 1-Bromo-2-Fluoro-3-(Trifluoromethyl)Benzene 1-Bromo-3-(Trifluoromethyl)Benzene 1-Chloro-2-(Trifluoromethoxy)Benzene 1-Chloro-2-(Trifluoromethyl)Benzene 1-Chloro-3-(Trifluoromethoxy)Benzene 1-Chloro-3-(Trifluoromethyl)Benzene 1-Chloro-4-(Trifluoromethoxy)Benzene 1-Fluoro-2-(Trifluoromethoxy)Benzene 1-Fluoro-2-(Trifluoromethyl)Benzene 1-Fluoro-3-(Trifluoromethyl)Benzene 1-Fluoro-4-(Trifluoromethoxy)Benzene 1-Fluoro-4-(Trifluoromethyl)Benzene 1-Iodo-2-(Trifluoromethyl)Benzene 1-Iodo-3-(Trifluoromethyl)Benzene 1-Methoxy-2-(Trifluoromethyl)Benzene 1-Methoxy-3-(Trifluoromethoxy)Benzene 1-Methoxy-3-(Trifluoromethyl)Benzene 1-Methoxy-4-(Trifluoromethyl)Benzene 1-Methyl-2-(Trifluoromethoxy)Benzene 1-Methyl-2-(Trifluoromethyl)Benzene 1-Methyl-3-(Trifluoromethyl)Benzene 1-Nitro-2-(Trifluoromethoxy)Benzene 1-Nitro-2-(Trifluoromethyl)Benzene 1-Nitro-3-(Trifluoromethoxy)Benzene 1-Nitro-3-(Trifluoromethyl)Benzene 1-Phenoxy-3-(Trifluoromethyl)Benzene 1-Phenoxy-4-(Trifluoromethyl)Benzene 1-Phenyl-3-(Trifluoromethyl)-1H-Pyrazole 2,2,2-Trifluoro-1-Phenylethan-1-Amine 2,2,2-Trifluoro-1-Phenylethan-1-Ol 2,2,2-Trifluoro-1-Phenylethan-1-One 2-(2,2,2-Trifluoroethoxy)Pyridine 2-(Trifluoromethoxy)Aniline 2-(Trifluoromethoxy)Benzaldehyde 2-(Trifluoromethoxy)Benzoic Acid 2-(Trifluoromethoxy)Benzonitrile 2-(Trifluoromethoxy)Phenol 2-(Trifluoromethoxy)Pyridine 2-(Trifluoromethyl)-1,1'-Biphenyl 2-(Trifluoromethyl)Aniline 2-(Trifluoromethyl)Benzaldehyde 2-(Trifluoromethyl)Benzamide 2-(Trifluoromethyl)Benzoic Acid 2-(Trifluoromethyl)Benzonitrile 2-(Trifluoromethyl)Phenol 2-(Trifluoromethyl)Pyrazine 2-(Trifluoromethyl)Pyridine 2-(Trifluoromethyl)Pyrimidine 2-(Trifluoromethyl)Quinazoline 2-(Trifluoromethyl)Thiazole 2-(Trifluoromethyl)Thiophene 2-Bromo-1-Fluoro-4-(Trifluoromethyl)Benzene 2-Bromo-4-(Trifluoromethyl)Aniline 2-Bromo-6-(Trifluoromethyl)Aniline 2-Chloro-3-(Trifluoromethyl)Aniline 2-Chloro-4-(Trifluoromethyl)Pyrimidine 2-Chloro-6-(Trifluoromethyl)Aniline 2-Methoxy-3-(Trifluoromethyl)Pyridine 2-Methoxy-5-(Trifluoromethyl)Pyridine 2-Phenoxy-5-(Trifluoromethyl)Pyridine 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5-(Trifluoromethyl)Pyridine 3-(Trifluoromethoxy)Aniline 3-(Trifluoromethoxy)Benzaldehyde 3-(Trifluoromethoxy)Benzoic Acid 3-(Trifluoromethoxy)Benzonitrile 3-(Trifluoromethoxy)Phenol 3-(Trifluoromethyl)-1H-Pyrrolo[2,3-B]Pyridine 3-(Trifluoromethyl)Aniline 3-(Trifluoromethyl)Benzaldehyde 3-(Trifluoromethyl)Benzenesulfonyl Chloride 3-(Trifluoromethyl)Benzoic Acid 3-(Trifluoromethyl)Benzonitrile 3-(Trifluoromethyl)Phenol 3-(Trifluoromethyl)Pyridazine 3-(Trifluoromethyl)Pyridin-2-Ol 3-(Trifluoromethyl)Pyridine 3-Chloro-4-(Trifluoromethyl)Aniline 4,4,4-Trifluoro-1-Phenylbutane-1,3-Dione 4,4,5,5-Tetramethyl-2-(2-(Trifluoromethyl)Phenyl)-1,3,2-Dioxaborolane 4,4,5,5-Tetramethyl-2-(3-(Trifluoromethoxy)Phenyl)-1,3,2-Dioxaborolane 4-(Trifluoromethoxy)Aniline 4-(Trifluoromethyl)-2H-Chromen-2-One 4-(Trifluoromethyl)Phenol 4-(Trifluoromethyl)Pyridine 4-(Trifluoromethyl)Pyrimidin-2-Amine 4-(Trifluoromethyl)Pyrimidine 4-(Trifluoromethyl)Thiazole 4-Bromo-3-(Trifluoromethyl)Aniline 5-(Trifluoromethyl)Pyridin-2-Amine 5-(Trifluoromethyl)Pyridin-2-Ol 6-(Trifluoromethyl)-1H-Indazole 6-(Trifluoromethyl)-1H-Indole 6-(Trifluoromethyl)Pyridin-2-Amine 6-(Trifluoromethyl)Pyridin-3-Amine Methyl 2-(Trifluoromethyl)Benzoate Methyl 3-(Trifluoromethyl)Benzoate N-Phenyl-4-(Trifluoromethyl)Aniline Phenyl(3-(Trifluoromethyl)Phenyl)Methanone Phenyl(Trifluoromethyl)Sulfane

By Key Group+−

(R)-2,2,2-Trifluoro-1-Ethanamine (S)-2,2,2-Trifluoro-1-Ethanamine (Trifluoromethyl)Thio 1,1,1,3,3,3-Hexafluoropropan-2-Ol 2,2,2-Trifluoro Ethanamine 2,2,2-Trifluoro Ethanol 2,2,2-Trifluoroacetamido 2,2,2-Trifluoroethoxy 2,2,2-Trifluoroethyl 4,4,4-Trifluoro-1,3-Dione Bistrifluoromethyl Bromo-Trifluoromethyl-Pyrazole Bromo-Trifluoromethyl-Pyridine Bromo-Trifluoromethyl-Pyrimidine Bromo-Trifluoromethyl-Quinoline Bromobenzotrifluoride Chloro-Iodo-Trifluoromethyl-Pyridine Chloro-Trifluoromethyl-Pyridin-Amine Chloro-Trifluoromethyl-Pyridine Chloro-Trifluoromethyl-Pyrimidine Chloro-Trifluoromethyl-Quinoline Chlorobenzotrifluoride Fluoro-Trifluoromethyl-Pyridine Fluorobenzotrifluoride Hydroxy-Trifluoromethyl Iodo-Trifluoromethyl-Pyridine Iodobenzotrifluoride Methoxy-Trifluoromethyl-Benzene Methoxy-Trifluoromethyl-Pyridine Nitro-Trifluoromethyl-Benzene Nitro-Trifluoromethyl-Pyridin Trifluoro-Ethanone Trifluoroacetic Trifluoromethanamine Trifluoromethyl-Acetophenone Trifluoromethyl-Amine Trifluoromethyl-Benzene-Sulfonyl Chloride Trifluoromethyl-Benzimidazole Trifluoromethyl-Benzo Trifluoromethyl-Benzothiazole Trifluoromethyl-Benzothiophene Trifluoromethyl-Benzoxazole Trifluoromethyl-Benzyl Trifluoromethyl-Chroman Trifluoromethyl-Cinnamic-Acid Trifluoromethyl-Furan Trifluoromethyl-Hydroxy-Quinoline Trifluoromethyl-Imidazo Trifluoromethyl-Imidazole Trifluoromethyl-Imidazopyridine Trifluoromethyl-Indazole Trifluoromethyl-Indene Trifluoromethyl-Indole Trifluoromethyl-Indoline Trifluoromethyl-Isoquinoline Trifluoromethyl-Nicotinate Trifluoromethyl-Nicotinic Acid Trifluoromethyl-Oxazole Trifluoromethyl-Phenyl-Acetate Trifluoromethyl-Phenyl-Borate Trifluoromethyl-Phenyl-Boronic Acid Trifluoromethyl-Phenyl-Ethanamine Trifluoromethyl-Phenyl-Ethanol Trifluoromethyl-Phenyl-Ethylamine Trifluoromethyl-Phenyl-Hydrazine Trifluoromethyl-Phenyl-Hydrochloride Trifluoromethyl-Phenyl-Methanamine Trifluoromethyl-Phenyl-Methanol Trifluoromethyl-Phenyl-Morpholine Trifluoromethyl-Phenyl-One Trifluoromethyl-Phenyl-Phosphino Trifluoromethyl-Phenyl-Piperazin Trifluoromethyl-Phenyl-Piperidine Trifluoromethyl-Phenyl-Propanol Trifluoromethyl-Phenyl-Pyrazin Trifluoromethyl-Phenyl-Pyrazol Trifluoromethyl-Phenyl-Pyrimidin Trifluoromethyl-Phenyl-Pyrrolidine Trifluoromethyl-Phenyl-Thiazole Trifluoromethyl-Phenyl-Urea Trifluoromethyl-Picolinamide Trifluoromethyl-Piperazine Trifluoromethyl-Piperidine Trifluoromethyl-Pyrazine Trifluoromethyl-Pyrazol-Amide Trifluoromethyl-Pyrazole Trifluoromethyl-Pyrazolone Trifluoromethyl-Pyridazine Trifluoromethyl-Pyridin-Amine Trifluoromethyl-Pyridin-Methanol Trifluoromethyl-Pyridine-Ethylamine Trifluoromethyl-Pyridyl-Methanamine Trifluoromethyl-Pyrimidin-Amine Trifluoromethyl-Pyrimidin-Ol Trifluoromethyl-Pyrrolo Trifluoromethyl-Quinazoline Trifluoromethyl-Quinolin-Amine Trifluoromethyl-Quinoxaline Trifluoromethyl-Sulfonyl Trifluoromethyl-Tetrahydroisoquinoline Trifluoromethyl-Thiazol Trifluoromethyl-Thio Trifluoromethyl-Thiophene Trifluoromethylaniline Trifluoromethylphenol Trifluoromethylphenyl Trifluoromethylpyridine Trifluoromethylpyridine-Indenoxazole Trifluoromethylpyrimidine Trifluoromethylquinoline Trifluoromethylsulfonyl Trifluorotoluene-Dioxaborane

By Parent Nucleus+−

Aliphatic Heterocycles Aromatic Heterocycles Azetidines Benzimidazoles Benzothiazoles Epoxides Furans Guanidines Imidazoles Imidazolines Indazoles Indoles Indolines Morpholines Other Aliphatic Heterocycles Other Aromatic Heterocycles Oxadiazoles Oxazoles Piperazines Piperidines Pyrans Pyrazines Pyrazoles Pyridazines Pyridines Pyrimidines Pyrroles Pyrrolidines Pyrrolines Quinazolines Quinolines Quinoxalines Spiroes Tetrahydroisoquinolines Tetrahydropyrans Thiazoles Thiazolidines Thiophenols Triazines Triazoles

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