Home Chemistry Heterocyclic Building Blocks Piperazines 1-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Piperazine
Suzuki Coupling: This reaction involves coupling the boron-containing compound with an aryl or vinyl halide in the presence of a palladium catalyst. It's a useful method for forming carbon-carbon bonds.
Hydrolysis: The boron-oxygen bond in the boronate ester can be hydrolyzed in the presence of an acid or base to produce the corresponding boronic acid and piperazine.
Oxidation: The boron atom can be oxidized to form a boronic acid derivative or a boroxine compound, depending on the choice of oxidizing agent.
Cross-Coupling Reactions: Other cross-coupling reactions like Stille, Negishi, or Hiyama coupling can be performed with the boron-containing compound as a reactant.
Functional Group Transformations: The phenyl and piperazine moieties in the molecule can undergo various functional group transformations, such as halogenation, amination, and acylation.
Reduction: The boron atom can be reduced to a boronate ester or boron hydride using appropriate reducing agents.
Boronate Ester Formation: The boron atom can form boronate esters with various electrophiles, such as alcohols, amines, or acids.
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4-(4-Acetyl-1-piperazinyl)phenylboronic Acid Pinacol Ester
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1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine hydrochloride
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4-(4-Methyl-1-piperazinyl)phenylboronic Acid Pinacol Ester
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4-[4-(N-Boc)piperazin-1-yl]phenylboronic acid pinacol ester
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2,2,2-Trifluoro-1-(4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazin-1-yl)ethanone
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1-Isopropyl-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine
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1-Isopropyl-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine hydrochloride
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1-Methyl-4-(2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine
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4-(4-Ethylpiperazin-1-yl)phenylboronic acid pinacol ester
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4-Piperazinylphenylboronic acid, pinacol ester
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