Home Chemistry Heterocyclic Building Blocks Pyridines 2-Chloro-4-Methylpyridine
Nucleophilic Substitution: The chlorine atom can be substituted by a nucleophile, such as amines or thiols, to yield substituted 4-methylpyridine derivatives.
Metalation: The hydrogen at the 2-position can be replaced by a metal, such as lithium or magnesium, to form organometallic intermediates.
Reduction: The chlorine atom can be reduced to a methyl group using reducing agents like lithium aluminum hydride or hydrogen in the presence of a catalyst.
Acylation and Alkylation: The nitrogen atom can undergo acylation or alkylation reactions under appropriate conditions, introducing acyl or alkyl groups onto the pyridine ring.
Ring-closure Reactions: It can undergo ring-closure reactions with suitable reagents to form cyclic compounds.
Oxidation: The methyl group can be oxidized to a carboxylic acid or an aldehyde under strong oxidizing conditions.
Halogenation: The pyridine ring can undergo halogenation at positions other than the chloro-substituted carbon, depending on the reaction conditions.
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3-Bromo-2-chloro-4-methyl-5-nitropyridine
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2-Chloro-4-methyl-6-(trifluoromethyl)pyridine
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6-Chloro-4-methylpyridine-2-carboxylic acid
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(6-Chloro-4-methylpyridin-2-yl)methanol
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2,5-Dichloro-4-methylpyridine-3-carbonitrile
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2-Chloro-4-methyl-pyridine-3-sulphonyl chloride
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2-Chloro-4-methyl-5-(trifluoromethyl)pyridine
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