Tie-2, a member of the Tie family of receptor tyrosine kinases, primarily interacts with angiopoietins to regulate angiogenesis and maintain vascular stability. This receptor is highly expressed in vascular endothelial cells, activating downstream pathways like PI3K/Akt, involved in vasculogenesis, vascular remodeling, and cell adhesion. The activity and expression levels of Tie-2 are closely associated with various diseases such as cancer angiogenesis, inflammatory responses, and certain genetic vascular diseases. Mutations or dysregulation in its gene can lead to abnormal vascular development, affecting disease progression.