Home Chemistry Heterocyclic Building Blocks Oxazoles 2-Phenyloxazole
Acylation and Alkylation: 2-Phenyloxazole can undergo acylation (replacement of hydrogen with an acyl group) and alkylation (replacement of hydrogen with an alkyl group) reactions. These reactions can be used to introduce various functional groups onto the oxazole ring.
Nucleophilic Substitution: The nitrogen atom in 2-phenyloxazole is nucleophilic and can react with electrophiles. This can lead to the substitution of the nitrogen atom with other groups.
Oxidation and Reduction: 2-Phenyloxazole can be subject to oxidation or reduction reactions. Oxidation may result in the formation of oxazole N-oxides, while reduction may yield dihydro-2-phenyloxazole derivatives.
Cyclization Reactions: 2-Phenyloxazole can participate in intramolecular cyclization reactions to form more complex fused ring systems.
Metal-Catalyzed Reactions: Transition metal catalysts can facilitate various reactions involving 2-phenyloxazole. For example, palladium or copper catalysts can be employed in cross-coupling reactions.
Nitration and Halogenation: 2-Phenyloxazole can be nitrated or halogenated at appropriate positions on the ring.
Heterocyclic Chemistry: 2-Phenyloxazole can participate in various reactions typical of heterocyclic compounds, such as reactions with bases, acids, and other heterocycles.
Photochemical Reactions: Like many aromatic compounds, 2-phenyloxazole can undergo photochemical reactions under suitable conditions.
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2-Phenyl-5-(trifluoromethyl)oxazole-4-carboxylic acid
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Methyl 2-(4-nitrophenyl)oxazole-4-carboxylate
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2-(4-Nitrophenyl)oxazole-4-carboxylic acid
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