MKLP (Mitotic Kinesin-Like Protein) family, including members such as MKLP1 and MKLP2, features critical kinase activity domains. These proteins are primarily localized in the cytoplasm at the spindle and midbody, involved in chromosome segregation and organelle distribution during mitosis. MKLP activates related signaling pathways to assist in the completion of cell mitosis. Specific gene expression is more pronounced in tissues with active cell division, while gene mutations may lead to abnormal division, affecting cell function and proliferation.