Home Chemistry Organic Building Blocks Fluorinated Building Blocks 3-Fluorobenzoic Acid
These compounds have the same murcko framework: benzene,and at least 2 kinds of functional groups( —F,—COOH).
Fluorine Substitution: Fluorobenzene can undergo further substitution reactions to replace the fluorine atom with other functional groups. This can be achieved through nucleophilic aromatic substitution reactions. The electron-withdrawing nature of fluorine can affect the regioselectivity and reactivity of such substitutions.
Esterification: Benzoic acid can undergo esterification reactions with 【alcohols|https://www.ambeed.com/alcohols.html】 in the presence of a catalyst, typically an acid catalyst like sulfuric acid. This reaction leads to the formation of benzoate 【esters|https://www.ambeed.com/esters.html】 and water.
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5-Fluoro-2-(methoxycarbonyl)benzoic acid
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5-Fluoro-2-(trifluoromethoxy)benzoic acid
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