Home Chemistry Heterocyclic Building Blocks Pyridines 5-Bromonicotinic Acid
Substitution Reactions: The bromine atom can undergo substitution reactions with various nucleophiles. For example, it can be replaced by another nucleophile such as hydroxide ion (OH⁻) to yield the corresponding hydroxy derivative.
Esterification: 5-Bromonicotinic acid can undergo esterification reactions with alcohols in the presence of acid catalysts to form esters.
Amide Formation: It can react with amines to form amide derivatives.
Decarboxylation: Under certain conditions, such as heating or treatment with strong acids, 5-bromonicotinic acid can undergo decarboxylation to yield the corresponding bromopyridine.
Metal Complex Formation: The carboxylic acid group can coordinate with metal ions to form metal complexes. This is particularly useful in metal-mediated organic transformations.
Coupling Reactions: 5-Bromonicotinic acid can participate in various coupling reactions, such as Suzuki coupling or Heck coupling, to form carbon-carbon bonds.
Oxidation and Reduction Reactions: The compound can undergo oxidation or reduction reactions depending on the reaction conditions and the choice of reagents.
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5-Bromo-2-(trifluoromethyl)nicotinic acid
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