Home Chemistry Organic Building Blocks Bromides 2-Bromo-4-Fluorobenzaldehyde
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Br,—CHO,—F).
Sonogashira Coupling: Bromobenzene can undergo coupling reactions with terminal 【alkynes|https://www.ambeed.com/alkynyls.html】 using a palladium catalyst, leading to the formation of substituted 【alkynes|https://www.ambeed.com/alkynyls.html】.
Heterocycle Formation: Benzaldehyde can participate in various reactions to form heterocyclic compounds, such as 【benzimidazoles|https://www.ambeed.com/benzimidazoles.html】 and 【benzothiazoles|https://www.ambeed.com/benzothiazoles.html】.
Fluorine Substitution: Fluorobenzene can undergo further substitution reactions to replace the fluorine atom with other functional groups. This can be achieved through nucleophilic aromatic substitution reactions. The electron-withdrawing nature of fluorine can affect the regioselectivity and reactivity of such substitutions.
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