Home Chemistry Organic Building Blocks Chlorides 3-Chloro-4-(Trifluoromethyl)Aniline
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Cl,—CF3,—NH2).
Electrophilic Substitution Reactions: Chlorobenzene's electron-rich aromatic ring can undergo substitution reactions where a hydrogen atom is replaced by a chlorine atom. For instance, it can undergo nitration, sulfonation, and Friedel-Crafts alkylation/acylation reactions.
Friedel-Crafts Acylation/Alkylation: The (trifluoromethyl)benzene can undergo Friedel-Crafts acylation or alkylation reactions, in which an acyl or alkyl group is added to the benzene ring. These reactions are catalyzed by Lewis acids and result in the formation of new carbon-carbon bonds.
Coupling Reactions: Aniline can participate in coupling reactions, such as Ullmann coupling, Buchwald-Hartwig coupling, and others, to form C-N bonds with various partner molecules.
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5-Chloro-2-nitro-4-(trifluoromethyl)aniline
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4-Chloro-5-(trifluoromethyl)benzene-1,2-diamine
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2-Bromo-5-chloro-4-(trifluoromethyl)aniline
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