Home Chemistry Heterocyclic Building Blocks Pyridines 3-Chloropyridin-2-Amine
Nucleophilic Substitution: The amine group can act as a nucleophile, attacking electrophilic centers. For example, it can undergo substitution reactions with alkyl halides or acyl chlorides to form N-alkyl or N-acyl derivatives.
Acylation: The amino group can undergo acylation reactions with acyl chlorides or acid anhydrides to form amides.
Reductive Amination: The amine group can participate in reductive amination reactions with carbonyl compounds, such as aldehydes or ketones, to form secondary or tertiary amines.
Metalation: The nitrogen atom can be metalated by strong bases like organolithium or organomagnesium reagents, leading to the formation of N-metalated derivatives.
Oxidation: The nitrogen atom can be oxidized to form various nitrogen-containing functional groups, such as oximes, nitro compounds, or N-oxides.
Heterocycle Formation: The molecule can undergo heterocyclization reactions to form fused heterocyclic compounds, particularly those involving the pyridine ring.
Reduction: The chloro group can be reduced to form a substituted amine, using reducing agents like lithium aluminum hydride or hydrogenation conditions.
Amidation: The amino group can react with carboxylic acids or their derivatives to form amides.
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3-Chloro-6-(trifluoromethyl)pyridin-2-amine
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2-Amino-3-chloro-5-(trifluoromethyl)pyridine
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