Home Chemistry Heterocyclic Building Blocks Pyridines 3-Bromo-2-Chloropyridin-4-Amine
Nucleophilic substitution: The bromine and chlorine atoms in the molecule are both good leaving groups, so nucleophiles can replace them at the 3-position or 4-position of the pyridine ring.
Palladium-catalyzed cross-coupling reactions: The bromine and chlorine atoms can serve as sites for palladium-catalyzed coupling reactions with various nucleophiles or electrophiles, such as Suzuki-Miyaura, Heck, or Stille reactions.
N-Arylation: The amino group can undergo N-arylation reactions with suitable electrophiles to introduce aryl substituents at the 4-position of the pyridine ring.
Reductive amination: The amino group can participate in reductive amination reactions with appropriate carbonyl compounds to form secondary or tertiary amines.
Alkylation or acylation: The amino group can undergo alkylation or acylation reactions under suitable conditions to introduce alkyl or acyl groups at the 4-position of the pyridine ring.
Heterocyclic synthesis: The molecule can participate in various heterocyclic synthesis reactions, such as condensation reactions with carbonyl compounds to form pyridine derivatives or heterocycle formation through cyclization reactions.
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3-Bromo-2-chloro-5-nitropyridin-4-amine
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