Home Chemistry Organic Building Blocks Bromides 1-Bromo-4-Fluoro-2-Methylbenzene
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Br,—CH3,—F).
Sonogashira Coupling: Bromobenzene can undergo coupling reactions with terminal 【alkynes|https://www.ambeed.com/alkynyls.html】 using a palladium catalyst, leading to the formation of substituted 【alkynes|https://www.ambeed.com/alkynyls.html】.
Sulfonation: Toluene can be sulfonated, leading to the introduction of a sulfonic acid group (-SO3H) onto the benzene ring. This is often carried out using concentrated sulfuric acid.
Cross-Coupling Reactions: Fluorobenzene can be utilized in cross-coupling reactions, such as Suzuki-Miyaura, Negishi, and Stille reactions. These reactions involve coupling a halogenated aromatic compound with an organometallic reagent, resulting in the formation of new carbon-carbon bonds.
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1-Bromo-4-fluoro-2-methyl-5-nitrobenzene
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1-Bromo-4-fluoro-2-methyl-3-nitrobenzene
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5-Bromo-2-fluoro-4-methylphenylboronic acid
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