Home Chemistry Heterocyclic Building Blocks Tetrahydropyrans 2-Phenoxytetrahydro-2H-Pyran
Nucleophilic Substitution: The oxygen atom in the phenoxy group (C6H5O-) can act as a nucleophile and undergo nucleophilic substitution reactions with electrophiles. For example, it can react with alkyl halides or acyl halides to form ether or ester derivatives, respectively.
Acid-Catalyzed Hydrolysis: 2-Phenoxytetrahydro-2H-pyran can undergo acid-catalyzed hydrolysis of the ether linkage, breaking the C-O bond and producing phenol and the corresponding alcohol.
Grignard Reaction: You can perform Grignard reactions using a phenylmagnesium bromide (PhMgBr) reagent to add a phenyl group to the molecule, replacing the phenoxy group with a phenyl group.
Reduction: Depending on the conditions, you can reduce the compound to yield different products. For example, catalytic hydrogenation can reduce the double bond in the tetrahydro-2H-pyran ring to form a saturated compound.
Arylation: You can perform palladium-catalyzed arylation reactions to introduce other aryl groups onto the phenyl ring.
Substitution Reactions: The compound can also undergo various substitution reactions at different positions, such as electrophilic aromatic substitution on the phenyl ring or nucleophilic substitution at the carbon adjacent to the oxygen in the tetrahydro-2H-pyran ring.
Cyclization Reactions: Depending on the reagents and conditions, you can promote intramolecular cyclization reactions to form cyclic compounds with different ring sizes.
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(4-((Tetrahydro-2H-pyran-2-yl)oxy)phenyl)boronic acid
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3-[(2-Tetrahydropyranyl)oxy]phenylboronic Acid
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4-((Tetrahydro-2H-pyran-2-yl)oxy)benzaldehyde
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