Ferroportin is a transmembrane iron ion transport protein primarily responsible for the efflux of iron ions from cells. It is composed of multiple transmembrane domains and is mainly located on the cell membrane of intestinal epithelial cells, macrophages, and hepatocytes. Ferroportin is involved in regulating the absorption, storage, and transport of iron ions, maintaining the homeostasis of iron ions in the body by transporting iron ions from the inside of cells to the plasma. The expression of ferroportin is tissue- and cell-specific, and mutations or dysregulation of its gene are associated with various diseases, including iron metabolism disorders, anemia, and hereditary hemochromatosis.