Home Chemistry Organic Building Blocks Ethers 1,2-Bis(Benzyloxy)Benzene
Hydrogenation: 1,2-bis(benzyloxy)benzene can be hydrogenated to produce 1,2-bis(benzyl)benzene. This reaction typically requires the use of a metal catalyst such as palladium or platinum and hydrogen gas.
Nucleophilic substitution: The benzyloxy groups on 1,2-bis(benzyloxy)benzene can be replaced by nucleophiles in a substitution reaction. For example, treatment with a strong nucleophile like sodium methoxide (NaOMe) can lead to the formation of sodium 1,2-bis(methoxy)benzene and benzyl alcohol as byproducts.
Acid-catalyzed hydrolysis: 1,2-bis(benzyloxy)benzene can be hydrolyzed in the presence of an acid (e.g., concentrated sulfuric acid) to produce 1,2-benzenediol (catechol) and benzyl alcohol.
Friedel-Crafts acylation or alkylation: The benzene rings in 1,2-bis(benzyloxy)benzene can undergo Friedel-Crafts reactions with acylating agents or alkylating agents in the presence of a Lewis acid catalyst. This can lead to the introduction of acyl or alkyl groups onto the benzene rings.
Oxidation: 1,2-bis(benzyloxy)benzene can be oxidized to form various products depending on the reaction conditions. Oxidation with strong oxidizing agents can lead to the formation of benzoquinone derivatives.
Reduction: The compound can undergo reduction reactions to convert the benzyloxy groups to benzyl groups or even to the corresponding diol if more vigorous reducing conditions are employed.
Debenzylation: Debenzylation reactions can be carried out to remove the benzyloxy groups and replace them with hydrogen or other functional groups. This can be accomplished using catalytic hydrogenation or other methods, such as treatment with acid or strong reducing agents.
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2-((3,4-Bis(benzyloxy)benzyl)amino)ethan-1-ol
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(((4-(Chloromethyl)-1,2-phenylene)bis(oxy))bis(methylene))dibenzene
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