Chemistry Heterocyclic building blocks Pyrazoles 3-cyclopropyl-1h-pyrazole

3-cyclopropyl-1h-pyrazole

Substitution Reactions: Depending on the specific substituents on the cyclopropyl-1H-pyrazole, it may undergo various substitution reactions, including electrophilic aromatic substitution, nucleophilic substitution, or radical substitution. Acylation: The nitrogen atoms in the pyrazole ring can undergo acylation reactions, typically with acyl halides or anhydrides to form amides. Alkylation: The nitrogen atoms in the pyrazole ring can also be alkylated using alkyl halides, providing N-alkylated pyrazoles. Ring-Opening Reactions: The cyclopropane ring in the cyclopropyl group can potentially undergo ring-opening reactions under certain conditions. Oxidation and Reduction: Depending on the reaction conditions, it can undergo oxidation or reduction reactions, typically with strong oxidizing or reducing agents, respectively. Condensation Reactions: If there are suitable functional groups, it may undergo condensation reactions with other compounds, forming new cyclic or acyclic products. Cycloaddition Reactions: Depending on the reagents and conditions, it might participate in cycloaddition reactions like [3+2] cycloadditions, which are common for pyrazole compounds. Isomerization: Depending on the substituents, it may undergo isomerization reactions, such as tautomerization.

Further Reading:

Framework+−

(1-methyl-1h-pyrazol-3-yl)methanol (1-phenyl-1h-pyrazol-4-yl)boronic acid 1,3-dimethyl-1h-pyrazole 1,3-diphenyl-1h-pyrazole 1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole 1,5-diphenyl-1h-pyrazole 1-(2-chlorophenyl)-1h-pyrazole 1-(3-chlorophenyl)-1h-pyrazole 1-(4-methoxybenzyl)-1h-pyrazole 1-(azetidin-3-yl)-1h-pyrazole 1-(tetrahydro-2h-pyran-2-yl)-1h-pyrazole 1-(tetrahydro-2h-pyran-4-yl)-1h-pyrazole 1-benzyl-1h-pyrazolo[3,4-b]pyridine 1-benzyl-4-bromo-1h-pyrazole 1-benzyl-4-iodo-1h-pyrazole 1-cyclopentyl-1h-pyrazole 1-cyclopropyl-1h-pyrazole 1-methyl-1h-pyrazol-3-amine 1-methyl-3-phenyl-1h-pyrazole 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-pyrazole 1-methyl-5-phenyl-1h-pyrazole 1-phenyl-1h-pyrazol-3-amine 1-phenyl-1h-pyrazol-3-ol 1-phenyl-1h-pyrazol-5-amine 1-phenyl-1h-pyrazole-3-carboxylic acid 1-phenyl-1h-pyrazole-4-carbaldehyde 1-phenyl-1h-pyrazole-4-carbonitrile 1-phenyl-1h-pyrazole-4-carboxylic acid 1-phenyl-1h-pyrazole-5-carboxylic acid 1-phenyl-3-(trifluoromethyl)-1h-pyrazole 1-trityl-1h-pyrazole 1h-pyrazol-4-amine 1h-pyrazol-4-ol 1h-pyrazol-5-amine 1h-pyrazole-4-carbaldehyde 1h-pyrazole-4-carbonitrile 1h-pyrazole-4-carboxylic acid 1h-pyrazole-4-sulfonyl chloride 1h-pyrazole-5-carboxamide 1h-pyrazole-5-carboxylic acid 1h-pyrazolo[3,4-b]pyrazine 1h-pyrazolo[3,4-b]pyridin-5-amine 1h-pyrazolo[3,4-d]pyrimidin-4-amine 1h-pyrazolo[4,3-d]pyrimidine 2,3-dihydropyrazolo[5,1-b]oxazole 2,4-dihydro-3h-pyrazol-3-one 2,6-di(1h-pyrazol-1-yl)pyridine 2-(1h-pyrazol-1-yl)pyridine 2-(1h-pyrazol-1-yl)pyrimidine 2-(1h-pyrazol-3-yl)pyridine 2-phenyl-2,4-dihydro-3h-pyrazol-3-one 3-(tert-butyl)-1-phenyl-1h-pyrazole 3-bromo-1-methyl-1h-pyrazole 3-bromopyrazolo[1,5-a]pyridine 3-bromopyrazolo[1,5-a]pyrimidine 3-chloro-1-methyl-1h-pyrazole 3-cyclopropyl-1h-pyrazole 3-iodo-1-methyl-1h-pyrazole 3-iodo-1h-pyrazolo[3,4-b]pyridine 3-methyl-1-phenyl-1h-pyrazole 3-phenyl-1h-pyrazol-5-amine 4,5,6,7-tetrahydro-1h-pyrazolo[3,4-c]pyridine 4,5,6,7-tetrahydro-1h-pyrazolo[4,3-c]pyridine 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine 4-(1h-pyrazol-1-yl)benzoic acid 4-(1h-pyrazol-1-yl)piperidine 4-bromo-1-methyl-1h-pyrazole 4-bromo-1-phenyl-1h-pyrazole 4-bromo-1h-pyrazolo[3,4-b]pyridine 4-bromopyrazolo[1,5-a]pyridine 4-chloro-1h-pyrazole 4-chloro-1h-pyrazolo[3,4-b]pyridine 4-chloro-1h-pyrazolo[3,4-d]pyrimidine 4-iodo-1h-pyrazole 4-methyl-1-phenyl-1h-pyrazole 4-methyl-1h-pyrazole 4-nitro-1h-pyrazole 4-phenyl-1h-pyrazole 5,6-dihydro-4h-pyrrolo[1,2-b]pyrazole 5-(difluoromethyl)-1h-pyrazole 5-bromo-1h-pyrazole 5-bromo-1h-pyrazolo[3,4-b]pyridine 5-bromo-1h-pyrazolo[3,4-c]pyridine 5-chloro-1h-pyrazole 5-chloro-1h-pyrazolo[3,4-b]pyridine 5-chloropyrazolo[1,5-a]pyrimidine 5-cyclopropyl-1h-pyrazole 5-iodo-1h-pyrazole 5-nitro-1h-pyrazole 5-nitro-1h-pyrazolo[3,4-b]pyridine 5-phenyl-1h-pyrazole-3-carboxylic acid 6,7-dihydro-5h-pyrazolo[5,1-b][1,3]oxazine 6-bromopyrazolo[1,5-a]pyridine 6-bromopyrazolo[1,5-a]pyrimidine 6-chloro-1h-pyrazolo[3,4-d]pyrimidine 7-chloropyrazolo[1,5-a]pyrimidine Ethyl 1-phenyl-1h-pyrazole-3-carboxylate Ethyl 1-phenyl-1h-pyrazole-4-carboxylate Ethyl 1h-pyrazole-4-carboxylate Ethyl pyrazolo[1,5-a]pyridine-3-carboxylate Ethyl pyrazolo[1,5-a]pyrimidine-3-carboxylate Methyl 1h-pyrazole-4-carboxylate Methyl 1h-pyrazolo[3,4-b]pyridine-5-carboxylate Methyl pyrazolo[1,5-a]pyridine-3-carboxylate Pyrazolo[1,5-a]pyrazine Pyrazolo[1,5-a]pyridine-2-carboxylic acid Pyrazolo[1,5-a]pyridine-3-carboxylic acid Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid Tert-butyl 1h-pyrazolo[3,4-b]pyridine-1-carboxylate Tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-pyrazole-1-carboxylate

By Key Group+−

Amino-pyrazole-carboxylate Amino-pyrazolopyridine Aminopyrazolo Benzylpyrazol-amide Bipyrazole Bromo-methyl-pyrazole Bromo-pyrazol-amide Bromo-pyrazole-carboxylate Bromo-pyrazolopyridine Bromo-pyrazolopyrimidine Bromo-trifluoromethyl-pyrazole Bromopyrazolo Chloro-methyl-pyrazole Chloro-pyrazolamide Chloro-pyrazole Chloro-pyrazole-carboxylate Chloro-pyrazolopyridine Chloro-pyrazolopyrimidine Chloropyrazolo Dichloropyrazolo Difluoromethyl-pyrazole Difluoromethyl-pyrazole-carboxylate Dihydropyrazolo Dimethyl-pyrazol-amide Dimethyl-pyrazole-carboxylate Dimethyl-pyrazole-carboxylic acid Dimethylpyrazole Dimethylpyrazolo Dioxaborolan-pyrazole Ethyl-pyrazol-amide Ethylpyrazole Fluoropyrazolo Hydroxy-pyrazole Hydroxy-pyrazolopyrimidine Hydroxypyrazolo Iodo-methyl-pyrazole Iodo-pyrazole-carboxylate Iodopyrazolo Isopropyl-pyrazol-amide Methoxy-pyrazolo-pyridine Methoxypyrazolo Methy-pyrazolooxazine Methyl-hydrox-ypyrazole Methyl-nitro-pyrazole Methyl-pyrazol-one Methyl-pyrazole-carboxylic acid Methyl-pyrazole-carboxylic-acid Methyl-pyrazolone Methyl-pyrazolopyridine Methylpyrazole Methylpyrazolo Nitro-pyrazole-carboxylate Phenyl-pyrazol-amide Phenyl-pyrazole-carboxylate Phenyl-pyrazolidine Phenylpyrazole Pyrazo-morpholine Pyrazol-amine Pyrazol-boronic acid Pyrazol-methanol Pyrazol-one Pyrazol-piperazine Pyrazol-pyridine Pyrazole-carbonitrile Pyrazole-carboxylate Pyrazole-carboxylic acid Pyrazole-ethanol Pyrazole-hydrochloride Pyrazole-methamine Pyrazole-phenyl-boronic-acid Pyrazole-piperidine Pyrazolo-pyrimidine Pyrazolooxazine Pyrazolopyrazine Pyrazolopyridin-ol Pyrazolopyridin-one Pyrazolopyridine Pyrazolopyridine-carbonitrile Pyrazolopyridine-carboxylate Pyrazolopyridine-carboxylic acid Pyrazolopyridine-carboxylic-acid Pyrazolopyridine-methanol Pyrazolopyrimid-one Pyrazolopyrimidine Pyrazolotriazine Pyridine-pyrazole Pyrimidine-pyrazole Pyrrolopyrazole Tetrahydropyran-pyrazole Tetrahydropyranopyrazole Tetrahydropyrazolo Trifluoromethyl-phenyl-pyrazol Trifluoromethyl-pyrazol-amide Trifluoromethyl-pyrazole Trifluoromethyl-pyrazolone

By Parent Nucleus+−

aliphatic heterocycles aromatic heterocycles azetidines furans guanidines imidazoles indazoles indoles other aliphatic heterocycles other aromatic heterocycles oxetanes piperazines Piperidines pyrazines pyridazines Pyridines Pyrimidines pyrroles pyrrolidines quinolines tetrahydrofurans tetrahydropyrans thiophenes

By Functional Group+−

alcohols aldehydes aliphatic chain hydrocarbons aliphatic cyclic hydrocarbons alkenyls alkyls alkynyls amides amines aryls benzyl bromides benzyl chlorides bromides carboxylic acids Chiral building blocks chlorides difluoromethyls esters ethers fluorinated building blocks hydrazones iodides ketones nitriles nitroes oximes phenols phosphoruses sulfamides sulfides sulfonates sulfonic acids sulfonyl chlorides trifluoromethyls ureas

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    3-Cyclopropyl-1H-pyrazole

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