Home Chemistry Organic Building Blocks Chlorides 2-Chloro-4-Methylbenzoic Acid
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Cl,—COOH,—CH3).
Electrophilic Substitution Reactions: Chlorobenzene's electron-rich aromatic ring can undergo substitution reactions where a hydrogen atom is replaced by a chlorine atom. For instance, it can undergo nitration, sulfonation, and Friedel-Crafts alkylation/acylation reactions.
Friedel-Crafts Acylation: Benzoic acid can undergo Friedel-Crafts acylation reactions with aromatic compounds in the presence of a Lewis acid catalyst such as aluminum chloride (AlCl3). This reaction results in the introduction of an acyl group (RCO-) onto the aromatic ring.
Nitration: Toluene can undergo nitration, where a nitro group (-NO2) is introduced onto the benzene ring. This reaction usually requires the presence of concentrated nitric acid and sulfuric acid as a catalyst.
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