Angiogenesis is a tightly regulated process that involves various cell types and molecular signals. It begins with the stimulation by a signaling protein known as Vascular Endothelial Growth Factor (VEGF), which promotes the proliferation and migration of endothelial cells. Besides VEGF, several other growth factors and extracellular matrix proteins are involved in regulating the formation of blood vessels. The balance of the angiogenic process is crucial for health, not only because it supports normal development and tissue repair but also because, in the context of diseases such as cancer development and inflammatory responses, excessive angiogenesis can facilitate tumor growth and metastasis.