Home Chemistry Heterocyclic Building Blocks Indazoles 7-Methoxy-1H-Indazole
Nucleophilic Substitution: The methoxy group can undergo nucleophilic substitution reactions with various electrophiles, leading to the formation of ether, ester , or other functionalized derivatives.
Electrophilic Substitution: The indazole ring can undergo electrophilic aromatic substitution reactions, such as halogenation, nitration, sulfonation, or Friedel-Crafts acylation/alkylation.
Reduction: The nitro group can be reduced to the corresponding amino group using reducing agents such as hydrogen gas over a metal catalyst or iron with hydrochloric acid.
Oxidation: The amino group can be oxidized to the corresponding nitro group using oxidizing agents such as nitric acid or potassium permanganate.
Ring-closure Reactions: The indazole ring may undergo ring-closure reactions under certain conditions, leading to the formation of fused ring systems or other cyclic compounds.
Substitution Reactions: Functional groups attached to the indazole ring can undergo substitution reactions, such as nucleophilic substitution or electrophilic substitution, depending on their nature.
Condensation Reactions: It can participate in condensation reactions with carbonyl compounds or other nucleophiles to form cyclic compounds or larger molecules.
Metalation Reactions: The indazole ring can be deprotonated with strong bases to form metalated intermediates, which can then undergo further reactions such as nucleophilic addition or substitution.
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Methyl 7-methoxy-1H-indazole-6-carboxylate
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