GDNF Receptor (Glial cell line-derived neurotrophic factor receptor) includes four main family members, GFRα1 to GFRα4, which interact with the Ret tyrosine kinase receptor complex. These receptors are primarily located on the cell surface and are involved in various tissue types, especially the nervous system. GDNF and its receptors function through signaling pathways that promote neuronal survival, growth, and repair. Specific gene expression and mutations can impact treatment strategies for neurological disorders, such as Parkinson's disease and other neurodegenerative diseases.