Home Chemistry Heterocyclic Building Blocks Indazoles 1H-Indazole-7-Carboxylic Acid
Esterification: The carboxylic acid group can undergo esterification reactions with alcohols to form esters.
Amide Formation: The carboxylic acid group can react with amines to form amides.
Decarboxylation: Under certain conditions, such as heating or treatment with specific reagents, decarboxylation may occur, leading to the loss of the carboxyl group and formation of the corresponding indazole derivative.
Substitution Reactions: The carboxylic acid group can undergo substitution reactions, such as nucleophilic substitution or electrophilic substitution.
Reduction: The carboxylic acid group can be reduced to the corresponding alcohol using reducing agents such as lithium aluminum hydride or sodium borohydride.
Oxidation: The nitrogen-containing heterocyclic ring can be oxidized to form various derivatives, such as N-oxides or imines.
Condensation Reactions: It can participate in condensation reactions with carbonyl compounds or other nucleophiles to form cyclic compounds or larger molecules.
Ring-opening Reactions: The indazole ring may undergo ring-opening reactions under certain conditions, leading to the formation of linear or branched compounds.
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