The Pim family comprises a group of serine/threonine kinases, including Pim-1, Pim-2, and Pim-3. These kinases are small, highly conserved intracellular proteins that can be activated without phosphorylation. Pim kinases are expressed in various cells and tissues, especially in immune cells and certain cancer cells. They participate in regulating signaling pathways involved in cell survival, proliferation, differentiation, and apoptosis by phosphorylating downstream target proteins such as AKT and BAD. Overexpression of Pim kinases is associated with the occurrence and development of various cancers, including lymphoma, prostate cancer, and leukemia. Additionally, due to their role in tumor cell survival and proliferation, Pim kinases have emerged as potential targets for cancer therapy.