Home Chemistry Heterocyclic Building Blocks Pyridines 3-Chloro-5-Methylpyridine
Nucleophilic Substitution: The chlorine atom can be replaced by a nucleophile (such as an amine or alcohol) to yield substituted products.
Metalation: The pyridine ring can be metalated by strong bases to form metal complexes, which can further undergo various reactions.
Acylation: The pyridine ring can undergo acylation reactions with acyl chlorides or acid anhydrides in the presence of a Lewis acid catalyst to form N-acylpyridinium salts.
Alkylation: The pyridine ring can be alkylated using alkyl halides or alkyl sulfonates under suitable reaction conditions.
Reduction: The chlorine atom can be reduced to a chloride anion, or the pyridine ring can be reduced to form tetrahydropyridine derivatives, depending on the choice of reducing agent and reaction conditions.
Oxidation: Depending on the reaction conditions, 3-chloro-5-methylpyridine can undergo oxidation to form various oxidation products, including pyridinium salts or other oxidized derivatives.
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1-(5-Chloro-3-methylpyridin-2-yl)ethanone
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1-(3-Chloro-5-methylpyridin-4-yl)ethanol
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1-(3-Chloro-5-methylpyridin-4-yl)ethan-1-one
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