Home Chemistry Heterocyclic Building Blocks Oxadiazoles 2,5-Diphenyl-1,3,4-Oxadiazole
Nucleophilic Substitution: 2,5-Diphenyl-1,3,4-oxadiazole can react with nucleophiles (compounds that donate electron pairs) to replace one or more of its substituents. For example, it can undergo nucleophilic substitution reactions at the oxygen or nitrogen atoms in the oxadiazole ring.
Electrophilic Substitution: It can also undergo electrophilic aromatic substitution reactions. For instance, the phenyl rings can react with electrophiles under appropriate conditions.
Reduction: 2,5-Diphenyl-1,3,4-oxadiazole can be reduced to the corresponding 2,5-diphenyl-1,3,4-thiadiazole using reducing agents like lithium aluminum hydride (LiAlH4).
Acylation and Alkylation: The compound can undergo acylation and alkylation reactions, where acyl or alkyl groups are added to the oxygen or nitrogen atoms in the oxadiazole ring.
Oxidation: It can be oxidized under certain conditions, leading to the formation of products with more oxygen-containing functional groups.
Ring Opening: Depending on the reaction conditions, it might undergo ring-opening reactions to form other compounds.
Heterocyclic Chemistry: 2,5-Diphenyl-1,3,4-oxadiazole can be used as a starting material in the synthesis of various heterocyclic compounds by incorporating it into more complex structures.
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2-(4-Bromophenyl)-5-phenyl-1,3,4-oxadiazole
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2-(3-Bromophenyl)-5-phenyl-1,3,4-oxadiazole
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4,4'-(1,3,4-Oxadiazole-2,5-diyl)diphenol
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