Soluble epoxide hydrolase (sEH) is an enzyme involved in fatty acid metabolism, primarily responsible for hydrolyzing endogenous epoxy fatty acids (EpFAs) such as epoxyeicosatrienoic acids (EETs) into their corresponding diol compounds (DHETs). sEH is mainly located in the cytoplasm and is expressed in tissues such as the liver, kidneys, and endothelial cells. sEH is involved in regulating blood pressure, inflammatory responses, and pain perception, among other biological processes, by affecting the levels of EpFAs and participating in various signaling pathways. The specific expression and mutations of the gene are associated with various diseases, including cardiovascular diseases, cancer, and inflammatory diseases.