Home Chemistry Heterocyclic Building Blocks Pyrans 3,4-Dihydro-2H-Pyran
Electrophilic Aromatic Substitution (EAS): If there are suitable substituents on the pyran ring, it can undergo EAS reactions. For example, you can introduce substituents like alkyl or halogen groups onto the aromatic ring through Friedel-Crafts acylation or alkylation reactions.
Hydrogenation: The double bonds present in 3,4-dihydro-2H-pyran can be hydrogenated to form a fully saturated pyran ring. This can be achieved using hydrogen gas and a suitable catalyst such as palladium on carbon (Pd/C).
Epoxidation: If there are double bonds in the pyran ring, they can be epoxidized using peracids like peracetic acid or m-chloroperbenzoic acid (MCPBA) to form Epoxides.
Nucleophilic Addition: 3,4-dihydro-2H-pyran can undergo nucleophilic addition reactions with various nucleophiles, such as Grignard reagents or organolithium compounds, leading to the formation of functionalized derivatives.
Ring Opening: The ring of 3,4-dihydro-2H-pyran can be opened under acidic or basic conditions, yielding compounds with open-chain structures.
Esterification: If there is a hydroxyl group present in the structure, it can be esterified using acid chlorides or anhydrides to form pyran-2-one esters.
Diels-Alder Reaction: 3,4-dihydro-2H-pyran can participate as a dienophile in Diels-Alder reactions with suitable dienes to form bicyclic compounds.
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(2R,3R,4R)-2-(Acetoxymethyl)-3,4-dihydro-2H-pyran-3,4-diyl diacetate
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