Home Chemistry Heterocyclic Building Blocks Piperidines 1-(Phenylsulfonyl)Piperidine
Nucleophilic Substitution: The sulfonate group (SO2Ph) can act as a good leaving group in certain conditions, allowing for nucleophilic substitution reactions. Nucleophiles can displace the sulfonyl group with their own functional group.
Reductive Processes: The phenylsulfonyl group may be subject to reduction under appropriate conditions, leading to the formation of a piperidine with a phenyl group attached.
Acid-Base Reactions: Like other secondary amines, piperidine can undergo acid-base reactions, with the lone pair of electrons on the nitrogen atom acting as a Lewis base. This can lead to the formation of piperidine salts or the deprotonation of piperidine.
Halogenation: Depending on the reaction conditions, you can potentially halogenate the piperidine ring or the phenylsulfonyl group. For example, you could react it with chlorine or bromine to form halogenated derivatives.
Oxidation: Under certain conditions, the phenylsulfonyl group can be oxidized to a sulfone (SO2R), resulting in the formation of an oxidized piperidine derivative.
Metalation Reactions: The piperidine ring can undergo metalation reactions with strong bases, resulting in the formation of piperidine-metal complexes.
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1-(4-Bromobenzenesulfonyl)piperidine-3-carboxylic acid
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1-((4-Chlorophenyl)sulfonyl)piperidine-4-carboxylic acid
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1-(Phenylsulfonyl)piperidine-4-carboxylic acid
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(4-(Piperidin-1-ylsulfonyl)-2-(trifluoromethyl)phenyl)boronic acid
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1-((3-Chloro-4-methylphenyl)sulfonyl)piperidine
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1-((3-Bromo-4-methylphenyl)sulfonyl)piperidine
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1-((4-Bromo-3-(trifluoromethyl)phenyl)sulfonyl)piperidine
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1-((5-Bromo-2-methoxyphenyl)sulfonyl)piperidine
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(2-(Piperidin-1-ylsulfonyl)phenyl)boronic acid
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(2-Methyl-5-(piperidin-1-ylsulfonyl)phenyl)boronic acid
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4-(Piperidin-1-ylsulfonyl)benzoyl chloride
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