The ALDH (Aldehyde Dehydrogenase) family is a group of enzymes responsible for oxidizing aldehyde compounds to their corresponding carboxylic acids. The family includes multiple subtypes, such as ALDH1A1, ALDH2, and ALDH3A1, each with different substrate specificities and tissue distributions. They consist of multiple functional domains and are primarily located in the cytoplasm, mitochondria, and nucleus. The ALDH family plays a crucial role in regulating the cellular redox state, alcohol metabolism, and the clearance of endogenous aldehydes. The expression of ALDH family members is tissue-specific, and mutations or dysregulation in their genes are associated with various diseases, including alcohol toxicity, cancer, and neurodegenerative diseases.