Home Chemistry Organic Building Blocks Bromides 3-Bromo-4-Fluorobenzamide
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Br,—F,—C(O)NH2).
Electrophilic Aromatic Substitution (EAS): Bromobenzene can react with electrophiles in substitution reactions, such as nitration, sulfonation, halogenation, and Friedel-Crafts acylation/alkylation.
Electrophilic Aromatic Substitution (EAS): Fluorobenzene can undergo typical electrophilic aromatic substitution reactions, similar to benzene. The fluorine atom, being electron-withdrawing, can influence the reactivity of the benzene ring. Common EAS reactions include nitration, halogenation, sulfonation, and Friedel-Crafts reactions.
Reduction: Benzamide can be reduced using reducing agents like lithium aluminum hydride (LiAlH4) to yield benzylamine, where the amide group is converted to an amine group.
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