Home Chemistry Heterocyclic Building Blocks Oxazoles 3,4-Diphenylisoxazole
Acylation: 3,4-diphenylisoxazole can undergo acylation reactions with acyl chlorides or anhydrides, leading to the formation of acylated products.
Reduction: The aromatic rings in 3,4-diphenylisoxazole can be reduced using reducing agents like lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4) to produce the corresponding dihydroisoxazole.
Halogenation: It can undergo halogenation reactions where the phenyl groups are substituted with halogen atoms (e.g., bromination or chlorination) in the presence of appropriate reagents.
Oxidation: 3,4-diphenylisoxazole can be oxidized to produce various products, depending on the reaction conditions. For instance, it can be oxidized to form isoxazole-4-carboxylic acid or other oxidized derivatives.
Cycloaddition: It can participate in various cycloaddition reactions, such as Diels-Alder reactions or 1,3-dipolar cycloadditions, depending on the reactants and conditions.
Base-Catalyzed Reactions: The isoxazole ring may undergo base-catalyzed reactions, such as ring opening or rearrangement reactions.
Metal-Catalyzed Reactions: Transition metal-catalyzed reactions can be employed to functionalize the isoxazole ring, including cross-coupling reactions and metal-catalyzed C-H activation reactions.
Substitution Reactions: The phenyl groups can undergo various substitution reactions, including nucleophilic aromatic substitution or electrophilic aromatic substitution, depending on the reaction conditions and reagents.
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4-(5-Methyl-3-phenylisoxazol-4-yl)benzene-1-sulfonyl chloride
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4-(5-Methyl-3-phenylisoxazol-4-yl)benzenesulfonic acid
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