GPR68 (OGR1) is a member of the G protein-coupled receptor family, characterized by seven transmembrane domains. It is widely expressed in various cells and tissues, including the cardiovascular system, kidneys, and immune system. As a pH-sensitive receptor, GPR68 is involved in regulating cellular responses to acidic environments, affecting cell proliferation, migration, and inflammatory responses. By activating signaling pathways such as IP3 and cAMP, GPR68 regulates various physiological and pathological processes. Its specific expression and functional regulation are significant in tumor development, cardiovascular diseases, and immune regulation. Mutations or aberrant expression of GPR68 are associated with the development of various diseases.