Chemistry Organic Building Blocks Nitriles 2-Chloro-6-Fluorobenzonitrile

2-Chloro-6-Fluorobenzonitrile

These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Cl,—C≡N,—F).

Electrophilic Substitution Reactions: Chlorobenzene's electron-rich aromatic ring can undergo substitution reactions where a hydrogen atom is replaced by a chlorine atom. For instance, it can undergo nitration, sulfonation, and Friedel-Crafts alkylation/acylation reactions.
Cyanohydrin Formation: Benzonitrile can react with carbonyl compounds in the presence of hydrogen cyanide (HCN) to form cyanohydrin compounds.
Electrophilic Aromatic Substitution (EAS): Fluorobenzene can undergo typical electrophilic aromatic substitution reactions, similar to benzene. The fluorine atom, being electron-withdrawing, can influence the reactivity of the benzene ring. Common EAS reactions include nitration, halogenation, sulfonation, and Friedel-Crafts reactions.

Further Reading:

Framework+−

1-Phenyl-1H-Pyrazole-4-Carbonitrile 1-Phenylcyclobutane-1-Carbonitrile 1-Phenylcyclopropane-1-Carbonitrile 1H-Imidazole-4-Carbonitrile 1H-Indazole-3-Carbonitrile 1H-Indole-2-Carbonitrile 1H-Indole-3-Carbonitrile 1H-Indole-5-Carbonitrile 1H-Indole-6-Carbonitrile 1H-Indole-7-Carbonitrile 1H-Pyrazole-4-Carbonitrile 1H-Pyrrole-2-Carbonitrile 1H-Pyrrole-3-Carbonitrile 2,3-Difluorobenzonitrile 2,4-Dichlorobenzonitrile 2,4-Difluorobenzonitrile 2,6-Dibromobenzonitrile 2,6-Dichlorobenzonitrile 2,6-Difluorobenzonitrile 2-(1,3,2-Dioxaborinan-2-Yl)Benzonitrile 2-(2-Bromophenyl)Acetonitrile 2-(2-Chlorophenyl)Acetonitrile 2-(2-Fluorophenyl)Acetonitrile 2-(3-Chlorophenyl)Acetonitrile 2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile 2-(4-(Benzyloxy)Phenyl)Acetonitrile 2-(Bromomethyl)Benzonitrile 2-(Piperazin-1-Yl)Benzonitrile 2-(Pyridin-2-Yl)Acetonitrile 2-(Pyridin-3-Yl)Acetonitrile 2-(Trifluoromethoxy)Benzonitrile 2-(Trifluoromethyl)Benzonitrile 2-Amino-3-Bromobenzonitrile 2-Amino-3-Chlorobenzonitrile 2-Amino-6-Chlorobenzonitrile 2-Aminonicotinonitrile 2-Bromo-6-Fluorobenzonitrile 2-Chloro-3-Methylbenzonitrile 2-Chloro-4-Fluorobenzonitrile 2-Chloro-6-Fluorobenzonitrile 2-Chloro-N-Methylaniline 2-Chlorobenzonitrile 2-Hydroxybenzonitrile 2-Iodobenzonitrile 2-Naphthonitrile 2-Nitrobenzonitrile 2-Oxo-2H-Chromene-3-Carbonitrile 2-Phenoxyacetonitrile 2-Phenoxybenzonitrile 2-Phenylacetonitrile 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile 3-(Trifluoromethoxy)Benzonitrile 3-(Trifluoromethyl)Benzonitrile 3-Bromo-2-Fluorobenzonitrile 3-Bromo-2-Hydroxybenzonitrile 3-Bromobenzonitrile 3-Chloro-2-Fluorobenzonitrile 3-Chlorobenzonitrile 3-Chloropyrazine-2-Carbonitrile 3-Fluoropicolinonitrile 3-Hydroxybenzonitrile 3-Iodobenzonitrile 3-Nitrobenzonitrile 3-Oxo-3-Phenylpropanenitrile 3-Phenoxybenzonitrile 4-Amino-2-Chlorobenzonitrile 4-Chloropyrimidine-5-Carbonitrile 4-Cyanophenyl Benzoate 4-Cyclohexylbenzonitrile 4-Fluorobenzonitrile 4-Nitrobenzonitrile 5-Fluoropicolinonitrile 6-Methylnicotinonitrile 6-Methylpicolinonitrile [1,1'-Biphenyl]-2-Carbonitrile [1,1'-Biphenyl]-4-Carbonitrile Benzo[B]Thiophene-2-Carbonitrile Benzo[D]Thiazole-2-Carbonitrile Benzonitrile Furan-2-Carbonitrile Imidazo[1,2-A]Pyridine-6-Carbonitrile Isonicotinonitrile Isoquinoline-1-Carbonitrile Methyl 2-Cyanobenzoate Methyl 3-Cyanobenzoate Morpholine-2-Carbonitrile Nicotinonitrile Pyrazine-2-Carbonitrile Pyrimidine-2-Carbonitrile Pyrimidine-4-Carbonitrile Pyrimidine-5-Carbonitrile Pyrrolidine-2-Carbonitrile Pyrrolidine-3-Carbonitrile Thiazole-5-Carbonitrile Thiophene-2-Carbonitrile Thiophene-3-Carbonitrile

By Key Group+−

2-Amino-Acetonitrile 2-Cyano-Acrylic Acid 2-Hydroxyacetonitrile 2-Methylpropanenitrile 3-Oxo-Propanenitrile Acetonitrile Acrylonitrile Amino-Cyano Aminoacetonitrile Aminobutanenitrile Aminocyclohexanecarbonitrile Benzimidazole-Nitrile Benzofuran-Carbonitrile Benzonitrile Benzopyran-Nitrile Benzothiazole-Nitrile Benzothiophene-Nitrile Bromobenzonitrile Bromonicotinonitrile Bromophenylacetonitrile Butanenitrile Butanenitrile Carbonyl Cyanide Chlorobenzonitrile Chloroisonicotinonitrile Chloronicotinonitrile Chromene-Carbonitrile Cyanide Cyanide Cyano-Methyl Cyanoacetamide Cyanoacetate Cyanobenzaldehyde Cyanobenzoate Cyanobenzoic Cyanocyclopropanecarboxylate Cyanoethyl Cyanoethyl Cyanoisonicotinate Cyanomethoxy Cyanomethyl Cyanomethyl Cyanonicotinate Cyanophenoxy Cyanophenyl Cyanophenylboronic Cyanopiperazine Cyanopiperidine Cyanopropan Cyanopropan Cyanopropanoate Cyanopyrrolidine Cyanotetrahydro Diacetonitrile Diaminobenzonitrile Dibromoisonicotinonitrile Dibromonicotinonitrile Dicarbonitrile Dicarbonitrile Dichlorobenzonitrile Dichloroisonicotinonitrile Difluorobenzonitrile Enecarbonitrile Ethyl Cyano-Carboxylate Fluorobenzonitrile Fluoroisonicotinonitrile Fluoroisophthalonitrile Fluoronicotinonitrile Fluorophenylacetonitrile Fluoropicolinonitrile Formylnicotinonitrile Formylnicotinonitrile Hydrazinylbenzonitrile Imidazolyl-Nitrile Imidazopyridine-Carbonitrile Indazole-Carbonitrile Indene-Carbonitrile Indole-Carbonitrile Indoline-Nitrile Iodobenzonitrile Iodonicotinonitrile Malononitrile Malononitrile Methoxyisonicotinonitrile Methoxyisonicotinonitrile Methoxynicotinonitrile Methoxynicotinonitrile Methylbutanenitrile Methylbutanenitrile Methylnicotinonitrile Methylnicotinonitrile Methylpropanenitrile Methylpropanenitrile Morpholine-Nitrile Nitropicolinonitrile Oxopentanenitrile Oxopentanenitrile Oxopropanenitrile Phenyl-Nitrile Phenylacrylonitrile Piperidine-Nitrile Propanenitrile Propanenitrile Pyrazino-Nitrile Pyrazole-Carbonitrile Pyrazolopyridine-Carbonitrile Pyrimidine-Nitrile Pyrimidinecarbonitrile Pyrrole-Carbonitrile Pyrrolidine-Nitrile Pyrrolopyridine-Carbonitrile Quinoline-Carbonitrile Tetracarbonitrile Tetracarbonitrile Tetrafluorobenzonitrile Tetrahydroquinoline-Carbonitrile Thiazole-Nitrile Thiocyanato Thiocyanatoaniline Thiophenecarbonitrile Thiopheno-Nitrile Triazole-Carbonitrile Tricarbonitrile Tricarbonitrile Trifluorobenzonitrile Trifluoromethylbenzonitrile

By Parent Nucleus+−

Aliphatic Heterocycles Aromatic Heterocycles Azetidines Benzimidazoles Benzisoxazoles Benzofurans Benzothiazoles Benzothiophenes Benzoxazoles Dioxolanes Epoxides Furans Guanidines Imidazoles Indazoles Indoles Indolines Isoquinolines Isothiazoles Isoxazoles Morpholines Non-Halogenated Heterocycles Other Aliphatic Heterocycles Other Aromatic Heterocycles Oxazoles Oxetanes Phthalazines Piperazines Piperidines Purines Pyrans Pyrazines Pyrazoles Pyridazines Pyridines Pyrimidines Pyrroles Pyrrolidines Quinazolines Quinolines Quinoxalines Quinuclidines Spiroes Tetrahydroisoquinolines Tetrahydropyrans Tetrahydroquinolines Thiazoles Thiazolidines Thiophenols Triazoles

By Functional Group+−

Acyl Chlorides Alcohols Aldehydes Aliphatic Chain Hydrocarbons Aliphatic Cyclic Hydrocarbons Alkenyls Alkyls Alkynyls Amides Amines Aryls Azoes Benzyl Bromides Benzyl Chlorides Bromides Carboxylic Acids Chiral Building Blocks Chlorides Difluoromethyls Esters Ethers Fluorinated Building Blocks Hydrazides Hydrazines Hydrazones Iodides Ketones Nitroes Oximes Phenols Phosphoruses Sulfamides Sulfides Sulfonates Sulfones Sulfonic Acids Sulfonyl Chlorides Thioesters Thiophenes Trifluoromethyls

Nitrogen related+−

R−C≡N

By Chemical Elements+−

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    Formula Weight+−

    cLogP+−

    H-Acceptors+−

    H-Donors+−

    Polar Surface Area+−

    Druglikeness+−

    NNCH/NNH+−

    sp3-Atoms+−

    Non-Aromatic Rings+−

    Aromatic Rings+−

    Rotatable Bonds+−

    By Configuration+−

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