Home Chemistry Organic Building Blocks Bromides 1-Bromo-3-Fluoro-2-Methoxybenzene
These compounds have the same murcko framework: benzene,and at least 3 kinds of functional groups( —Br,—OCH3,—F).
Sonogashira Coupling: Bromobenzene can undergo coupling reactions with terminal 【alkynes|https://www.ambeed.com/alkynyls.html】 using a palladium catalyst, leading to the formation of substituted 【alkynes|https://www.ambeed.com/alkynyls.html】.
Catalytic Oxidation: Methoxybenzene can be oxidized to form methoxybenzoquinone using catalytic amounts of oxidizing agents like palladium(II) acetate.
Cross-Coupling Reactions: Fluorobenzene can be utilized in cross-coupling reactions, such as Suzuki-Miyaura, Negishi, and Stille reactions. These reactions involve coupling a halogenated aromatic compound with an organometallic reagent, resulting in the formation of new carbon-carbon bonds.
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1-Bromo-4-chloro-3-fluoro-2-methoxybenzene
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(5-Bromo-2,3-difluoro-4-methoxyphenyl)boronic acid
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4-Bromo-2-fluoro-3-methoxybenzonitrile
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(4-Bromo-2-fluoro-3-methoxyphenyl)boronic acid
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