Home Chemistry Heterocyclic Building Blocks Pyridines 5-Methylpyridin-3-Amine
Acylation: The amine group can undergo acylation reactions, where it can be acylated with acyl chlorides or acid anhydrides to form amides.
Alkylation and Arylation: The amine nitrogen can undergo alkylation or arylation reactions with alkyl or aryl halides under appropriate conditions.
N-Acylation: The amine nitrogen can react with acyl chlorides or acid anhydrides to form N-acyl derivatives.
Reductive Amination: The amine group can participate in reductive amination reactions with carbonyl compounds in the presence of reducing agents to form secondary or tertiary amines.
Substitution Reactions: The aromatic ring can undergo substitution reactions such as electrophilic aromatic substitution (EAS) where the methyl group at the 5-position can direct substitution reactions.
Oxidation: Both the amine group and the methyl group can undergo oxidation under appropriate conditions.
Condensation Reactions: The amine group can participate in condensation reactions with carbonyl compounds to form imines or Schiff bases.
Hofmann Elimination: Under certain conditions, the amine group can undergo Hofmann elimination to form an alkene.
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