Home Chemistry Heterocyclic Building Blocks Pyridines 2-Bromo-6-(Trifluoromethyl)Pyridine
Nucleophilic substitution: The bromine atom can be replaced by a nucleophile, such as an amine or an alkoxide ion, leading to the formation of substituted pyridines.
Palladium-catalyzed coupling reactions: The trifluoromethyl group can undergo cross-coupling reactions with aryl or vinyl halides under palladium catalysis, leading to the formation of biaryl or vinylic compounds.
Electrophilic aromatic substitution: The electron-rich pyridine ring can undergo electrophilic aromatic substitution reactions with electrophiles, such as acyl chlorides or nitro compounds, leading to the formation of substituted pyridines.
Metalation: The pyridine ring can be deprotonated at the 2-position using strong bases, such as butyllithium or sodium amide, leading to the formation of pyridine metal complexes which can further participate in various reactions.
Redox reactions: The compound can undergo oxidation or reduction reactions depending on the reaction conditions and the presence of suitable reagents.
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2,4-Dibromo-6-(trifluoromethyl)pyridin-3-amine
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2-Bromo-3-nitro-6-(trifluoromethyl)pyridine
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(2-Bromo-6-(trifluoromethyl)pyridin-3-yl)boronic acid
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3-Amino-2-bromo-6-(trifluoromethyl)pyridine
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2-Bromo-4-methyl-6-(trifluoromethyl)pyridin-3-amine
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