Home Chemistry Heterocyclic Building Blocks Pyridines Methyl 3-Bromopicolinate
Substitution Reactions: The bromine atom can undergo nucleophilic substitution reactions. For instance, it can be substituted by other nucleophiles such as amines, thiols, or cyanide ions.
Ester Hydrolysis: The ester group can undergo hydrolysis under acidic or basic conditions, yielding the corresponding carboxylic acid and methanol.
Grignard Reaction: Methyl 3-bromopicolinate can react with a Grignard reagent to form a new carbon-carbon bond, typically resulting in the formation of a tertiary alcohol.
Reduction Reactions: The bromine atom or the ester group can be selectively reduced using appropriate reducing agents to produce different products such as alcohols or alkyl halides.
Palladium-Catalyzed Coupling Reactions: Methyl 3-bromopicolinate can undergo palladium-catalyzed coupling reactions with various nucleophiles or organometallic reagents to form biaryl compounds or other functionalized products.
Elimination Reactions: Under appropriate conditions, elimination reactions can occur, leading to the formation of alkene products.
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Methyl 3-bromo-6-(trifluoromethyl)picolinate
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Methyl 3-bromo-5-(trifluoromethyl)picolinate
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