Home Chemistry Organic Building Blocks Esters Benzyl Cyclohexylcarbamate
Hydrolysis: Under acidic or basic conditions, benzyl cyclohexylcarbamate can undergo hydrolysis to form benzylamine and cyclohexyl isocyanate.
Reductive Amination: It can be used in reductive amination reactions to introduce an amine group onto another compound.
Hofmann Rearrangement: Treatment with hypochlorite (NaOCl) and base can lead to the Hofmann rearrangement, converting it into benzylamine.
Protection/Deprotection: The benzyl group can be selectively removed using acid or hydrogenation conditions. This is often used to protect other functional groups during chemical synthesis.
Amidation: Benzyl cyclohexylcarbamate can participate in amidation reactions with various carboxylic acids to form amides.
Reduction: The carbamate group can be reduced to the corresponding amine using reducing agents like lithium aluminum hydride (LiAlH4) or sodium borohydride (NaBH4).
Substitution Reactions: The benzyl group can undergo substitution reactions such as nucleophilic aromatic substitution or metal-catalyzed cross-coupling reactions.
Cyclization: Depending on the reaction conditions and reagents, cyclization reactions can occur, leading to the formation of cyclic compounds.
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(1R,3S)-rel-3-(((Benzyloxy)carbonyl)amino)cyclohexanecarboxylic acid
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Benzyl (trans-4-hydroxycyclohexyl)carbamate
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trans-4-(((Benzyloxy)carbonyl)amino)cyclohexanecarboxylic acid
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Benzyl ((1R,2R)-2-aminocyclohexyl)carbamate
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Benzyl (cis-4-(hydroxymethyl)cyclohexyl)carbamate
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Benzyl (trans-4-aminocyclohexyl)carbamate hydrochloride
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