Home Chemistry Heterocyclic Building Blocks Thiadiazoles 1,2,3-Thiadiazole
Electrophilic Substitution: 1,2,3-Thiadiazole can undergo electrophilic aromatic substitution reactions, similar to benzene. For example, it can react with electrophiles such as halogens (chlorine, bromine), nitration reagents, or sulfonation reagents to introduce substituents onto the thiadiazole ring.
Nucleophilic Substitution: The sulfur atom in 1,2,3-thiadiazole can act as a nucleophile, participating in reactions with electrophiles. This can lead to the formation of various functionalized derivatives.
Oxidation: 1,2,3-Thiadiazole can be oxidized to produce various oxidation products. For example, it can be oxidized to the corresponding sulfoxide or sulfone.
Reduction: Reduction reactions can reduce the sulfur atoms in 1,2,3-thiadiazole to produce different products, such as thiol derivatives.
Ring-Opening Reactions: Depending on the reaction conditions and reagents, 1,2,3-thiadiazole can undergo ring-opening reactions to form open-chain compounds with appropriate substituents.
Cyclization Reactions: 1,2,3-Thiadiazole can be used as a starting material for the synthesis of more complex heterocyclic compounds through cyclization reactions.
Functional Group Transformations: Various functional groups can be introduced onto the 1,2,3-thiadiazole ring through suitable reactions, such as acylation, alkylation, and halogenation.
Coordination Chemistry: 1,2,3-Thiadiazole can act as a ligand in coordination chemistry, forming complexes with metal ions.
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4-Methyl-1,2,3-thiadiazole-5-carboxylic acid
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Ethyl 4-methyl-1,2,3-thiadiazole-5-carboxylate
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4-(Hydroxymethyl)-1,2,3-thiadiazole-5-carboxylic acid
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5-(Chloromethyl)-4-isopropyl-1,2,3-thiadiazole
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