Home Chemistry Heterocyclic Building Blocks Indoles 1-(1H-Indol-1-Yl)Ethan-1-One
Nucleophilic Addition to the Carbonyl Group: The ketone group can undergo nucleophilic addition reactions, particularly with nucleophiles such as organometallic reagents or amines, leading to the formation of alcohols or amine derivatives.
Aldol Reaction: The ketone group can participate in aldol condensation reactions, especially if the conditions are basic. This could result in the formation of a β-hydroxy ketone.
Reduction of the Ketone: The ketone functionality can be reduced to the corresponding alcohol using reducing agents like sodium borohydride or lithium aluminum hydride.
Indole Ring Reactions: The indole ring is known for its reactivity in various aromatic substitution reactions. For example, it may undergo electrophilic substitution reactions with electrophiles (e.g., Friedel-Crafts acylation or alkylation) under appropriate conditions.
Nucleophilic Substitution on the Indole Ring: The indole nitrogen can participate in nucleophilic substitution reactions with suitable electrophiles.
Fischer Indole Synthesis: Under acidic conditions, the compound might undergo Fischer indole synthesis, resulting in the formation of a substituted indole.
Condensation Reactions: The compound could undergo condensation reactions with other compounds containing reactive functional groups.
Oxidation: The indole-3-acetylacetone may be oxidized under certain conditions, leading to the formation of carboxylic acids.
Enamine Formation: The ketone group may react with a secondary amine|http://www.ambeed.com/amines.html to form an enamine, which can undergo further reactions.
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1-Acetyl-5-bromo-4-chloro-1H-indol-3-yl acetate
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