Pyk2 (Proline-rich tyrosine kinase 2), also known as FAK2 (Focal adhesion kinase 2), is a member of the FAK (Focal adhesion kinase) family. It consists of a FERM domain, a tyrosine kinase catalytic domain, and a C-terminal region. Pyk2 is primarily expressed in the brain, heart, and immune cells, where it regulates cell migration, proliferation, and survival. It is activated by receptors such as integrins and GPCRs, participating in multiple signaling pathways such as calcium signaling and the MAPK pathway. The expression and activity of Pyk2 are regulated in neurological disorders, cardiovascular diseases, and cancer. Its specific gene expression patterns and potential mutations are of significant importance in the development of diseases, making it a novel research and therapeutic target.