Home Chemistry Heterocyclic building blocks Azetidines 3-methyleneazetidine
Addition Reactions: The methylene group in 3-methyleneazetidine can undergo addition reactions with various nucleophiles or electrophiles, depending on reaction conditions.
Ring-Opening Reactions: Due to the strain in the four-membered ring, 3-methyleneazetidine can undergo ring-opening reactions to form open-chain compounds. This can occur under acidic or basic conditions.
Cycloaddition Reactions: 3-methyleneazetidine can participate in cycloaddition reactions with suitable dienophiles or dipolarophiles to form cyclic compounds with different ring sizes.
Substitution Reactions: The methylene group can undergo substitution reactions with appropriate reagents or nucleophiles to introduce various functional groups.
Reduction Reactions: The double bond in the methylene group can be reduced to form a saturated compound.
Elimination Reactions: Under certain conditions, 3-methyleneazetidine can undergo elimination reactions to form conjugated systems or double bonds.
Hydrolysis: 3-methyleneazetidine can be hydrolyzed under acidic or basic conditions to break the ring and form open-chain compounds.
Oxidation Reactions: Depending on reaction conditions, the methylene group can be oxidized to form various functional groups, such as ketones or carboxylic acids.
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tert-Butyl 3-(cyanomethylene)azetidine-1-carboxylate
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tert-Butyl 3-methyleneazetidine-1-carboxylate
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tert-Butyl 3-(2-ethoxy-2-oxoethylidene)azetidine-1-carboxylate
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2-(1-(tert-Butoxycarbonyl)azetidin-3-ylidene)acetic acid
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tert-Butyl 3-(2-methoxy-2-oxoethylidene)azetidine-1-carboxylate
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2-(1-(Methylsulfonyl)azetidin-3-ylidene)acetonitrile
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2-(1-(Ethylsulfonyl)azetidin-3-ylidene)acetonitrile
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2-(Azetidin-3-ylidene)acetonitrile hydrochloride
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