Home Chemistry Heterocyclic Building Blocks Indazoles 4-Nitro-1H-Indazole
Reduction: The nitro group (-NO2) can be reduced to the corresponding amine group (-NH2) using reducing agents such as iron and hydrochloric acid (Fe/HCl), tin and hydrochloric acid (Sn/HCl), or catalytic hydrogenation.
Nucleophilic Substitution: The nitro group can undergo nucleophilic substitution reactions with various nucleophiles, such as organometallic reagents (e.g., Grignard reagents), to form substituted derivatives.
Aromatic Substitution: The nitro group can undergo electrophilic aromatic substitution reactions, such as nitration, to introduce substituents onto the aromatic ring.
Amidation: The nitro group can react with amines under appropriate conditions to form amides.
Reductive Amination: The nitro group can be converted to an amine group followed by reductive amination reactions with carbonyl compounds to form secondary amines.
Condensation Reactions: 4-nitro-1H-indazole can participate in condensation reactions with carbonyl compounds or other nucleophiles to form cyclic compounds or larger molecules.
Cyclization Reactions: 4-nitro-1H-indazole can undergo cyclization reactions with appropriate reagents to form fused heterocyclic compounds or other ring systems.
Oxidation: 4-nitro-1H-indazole can be oxidized under suitable conditions to form nitroso or other oxidized derivatives.
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Methyl 4-nitro-1H-indazole-6-carboxylate
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