Chemistry Heterocyclic Building Blocks Benzisoxazoles

Benzisoxazoles

An organic compound that contains a fused ring structure of benzene and isoxazole is known as 1,2-benzisoxazole, with a molecular formula of C7H5NO. This compound is classified as aromatic.

Benzisoxazoles and benzisoxazoyls that have been functionalized are utilized in various ways, which encompass the production of pharmaceutical drugs like certain antipsychotics (such as risperidone, paliperidone, ocaperidone, and iloperidone) as well as the anticonvulsant zonisamide.

The thermal stability of Benzisoxazoles, isoxazoles, isoxazolines, and isoxazolidines allows them to distill without undergoing decomposition, however, the substitution pattern plays a crucial role in determining the system's stability.

Benzisoxazoles are found to display a variety of biological activities such as antihelmintic, anticonvulsant, antipsychotic, antihistaminic, anticancer, antiviral, antiproliferative, antiinflammatory, antioxidant, antidepressant, hypertensive, anticonvulsant, and anticoagulant properties. 

Benzisoxazole, which can also be referred to as anthranil, benzo[d]isoxazole, or benz[c]isoxazole, is an organic compound that features an isoxazole ring fused with a benzene ring. Due to its aromatic nature, it displays a considerable degree of stability, while its reactive sites enable functionalization.

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    5-Iodobenzo[d]isoxazole

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    (6-Fluorobenzo[d]isoxazol-3-yl)methanol

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    Benzo[c]isoxazol-3(1H)-one

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    3-(Chloromethyl)-6-fluorobenzo[d]isoxazole

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    Methyl 6-bromobenzo[d]isoxazole-3-carboxylate

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    1,2-Benzisoxazole-3-acetic Acid

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    1,2-Benzisoxazole-3-acetic Acid

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    6-Fluorobenzo[d]isoxazol-3-ylamine

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    6-Fluorobenzo[d]isoxazol-3-ylamine

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