Home Chemistry Heterocyclic Building Blocks Indoles 3-(Piperidin-4-Yl)-1H-Indole
Acylation: The piperidine nitrogen can be acylated using acyl chlorides or anhydrides, leading to the formation of amides.
Alkylation or Arylation: The piperidine nitrogen can be alkylated or arylated with alkyl or aryl halides under appropriate conditions.
Nucleophilic Substitution: The indole ring is susceptible to nucleophilic substitution reactions. For instance, it can react with electrophiles in the 2- or 3-position.
Ring Opening: The piperidine ring can undergo ring-opening reactions with various nucleophiles, such as alkyl halides or acyl chlorides, leading to the formation of substituted products.
Reduction: The indole ring may be reduced under certain conditions, converting the double bond to a single bond.
Oxidation: The compound can be oxidized to introduce functional groups.
Grignard Reaction: The compound may undergo a Grignard reaction with a suitable Grignard reagent to introduce new substituents.
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tert-Butyl 4-(1H-indol-3-yl)piperidine-1-carboxylate
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4-Fluoro-3-(piperidin-4-yl)-1H-indole
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5-Chloro-2-methyl-3-(piperidin-4-yl)-1H-indole
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