The Corticotropin-Releasing Factor Receptor (CRF receptor) is a member of the G protein-coupled receptor (GPCR) family, mainly including two subtypes: CRF1 and CRF2. These receptors are composed of seven transmembrane domains and are primarily located on the cell membrane. CRF receptors are expressed in the brain, pituitary gland, and other tissues, participating in the regulation of stress response, mood regulation, and energy balance. They regulate various physiological and behavioral responses by activating the cAMP signaling pathway and other downstream effectors. The tissue-specific expression and mutations of CRF receptor genes are associated with various diseases, including depression, anxiety disorders, and obesity.