Home Chemistry Heterocyclic Building Blocks Pyridines 2-(Piperidin-1-Yl)Pyridine
Nucleophilic Substitution: The piperidine nitrogen atom can act as a nucleophile in substitution reactions. For example, it can react with alkyl halides to form N-alkylated piperidine derivatives.
Acylation: 2-(piperidin-1-yl)pyridine can undergo acylation reactions, where an acyl group (-COR) replaces a hydrogen atom on the nitrogen atom of the piperidine ring.
Alkylation: It can be alkylated by reacting it with alkylating agents, resulting in N-alkylated or N,N-dialkylated products.
Heterocyclization: Depending on the reaction conditions, it can participate in various heterocyclization reactions to form different cyclic compounds.
Metalation: The pyridine ring can undergo metalation with various metals, such as lithium, magnesium, or zinc, to form organometallic complexes.
Halogenation: The pyridine ring can be halogenated at different positions when treated with halogenating agents like bromine or chlorine.
N-oxidation: The piperidine nitrogen can be oxidized to form N-oxides using oxidizing agents like hydrogen peroxide or m-chloroperbenzoic acid.
Amidation: The amine group of the piperidine can react with acyl chlorides or anhydrides to form amides.
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Methyl 2-(4-aminopiperidin-1-yl)nicotinate
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1-(5-(Trifluoromethyl)pyridin-2-yl)piperidine-4-carboxylic acid
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1-(Pyridin-2-yl)piperidine-4-carboxylic acid
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1-(5-Fluoropyridin-2-yl)piperidin-4-ol
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