The TET (Ten-Eleven Translocation) family is a group of iron and α-ketoglutarate-dependent DNA demethylases, including TET1, TET2, and TET3. They possess catalytic CXXC domains and dioxygenase domains. TET proteins are primarily located in the cell nucleus, participating in the dynamic regulation of DNA methylation, converting 5-methylcytosine into 5-hydroxymethylcytosine, thereby promoting DNA demethylation. Specific expression and mutation of TET gene are associated with many diseases, including cancer, hematological disorders, and neurodevelopmental disorders. For example, mutations in TET2 are associated with the occurrence of certain myeloproliferative disorders and acute myeloid leukemia.