Home Chemistry Heterocyclic Building Blocks Indazoles 1H-Indazol-3-Ol
Substitution Reactions: The hydroxyl group can undergo substitution reactions with various electrophiles, such as alkyl halides or acyl chlorides, leading to the formation of substituted products.
Oxidation: The alcohol group can be oxidized to the corresponding aldehyde or carboxylic acid under appropriate conditions.
Esterification: The hydroxyl group can react with carboxylic acids or acid derivatives to form esters through esterification reactions.
Ring Closure Reactions: The hydroxyl group can participate in intramolecular reactions, leading to the formation of cyclic compounds or heterocycles.
Nucleophilic Addition Reactions: The hydroxyl group can undergo nucleophilic addition reactions with electrophiles, such as ketones or aldehydes, to form hemiacetals or acetals.
Protonation: The hydroxyl group can be protonated under acidic conditions to form the corresponding oxonium ion.
Dehydration: Under appropriate conditions, dehydration reactions can occur to eliminate water and form unsaturated compounds.
Substitution at the Indazole Ring: The nitrogen atom in the indazole ring can undergo substitution reactions with various electrophiles, leading to the formation of substituted indazoles.
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