LTA4H (Leukotriene A4 hydrolase) is a zinc-dependent metalloproteinase belonging to the leukotriene synthase family. It consists of a catalytic domain and a metal binding domain. LTA4H is mainly located in the cytoplasm and cell membrane, participating in the leukotriene metabolic pathway by converting leukotriene A4 (LTA4) into leukotriene B4 (LTB4) and leukotriene C4 (LTC4), thereby regulating inflammation and immune responses. LTA4H is expressed in various cell types and tissues, including leukocytes, lungs, and liver. Its specific expression and mutations are associated with the development of various diseases, including asthma, chronic obstructive pulmonary disease, and cardiovascular diseases.